Mehrano Wildlife Sanctuary is an enhanced riverine forest privately preserved by the Talpur Mir royal family of Khairpur Princely state.
Mhrano Wildlife Sanctuary is endorsed by the Sindh wildlife department.

It comprises agricultural land, forest, and hunting area and is home to various flora and fauna.
Mehrano Forest is the home to approximately 4,000 big game animals, including blackbuck, Indian gazelle, hog deer, wild boar.

The forest lake boasts resident and migratory birds from Siberia and Europe.

There is a reserved place for tourist to see furious wild boars, which are called upon in a unique way by the caretaker, who wears an orange Russian cap.

H. H. Mir Ali Murad Khan Talpur II, Head of the royal house, as long taken a keen interest in animal welfare and conservation, having established one of the largest private wildlife sanctuaries on the sub-continent.

His younger son, Prince Mehdi Raza Khan, continues his father's passion and oversees his conservation interests since retirement.

H. H. Mir Ali Murad Khan Talpur II has forbidden all hunting except of the jackal and an annual culling of wild boars which become a mortal threat to adjacent farmers and their families when boar population becomes too large for the forest to hold.

The Mehrano reserve shares its boundary with the Cholistan desert.