The Kirthar National Park is situated in the Kirthar Mountains in Karachi and Jamshoro District in Sindh, Pakistan.

The maximum elevation in the Sindh segment of the mountains was reported in April 2009, as 7,056 ft (2,151 m) above sea-level.

The mountains extend southward for about 190 mi (310 km) from the Mula River in east-central Balochistan to Cape Monze on the Arabian Sea.

The Kirthar Mountains form the boundary between the lower Indus Plain (to the east) and southern Balochistan (to the west).

It consists of a series of parallel rock hill ridges rising from 4,000 ft (1,200 m) in the south to nearly 8,000 ft (2,400 m) in the north.

The park was founded in 1974 and stretches over 3,087 square kilometres (1,192 sq mi), making it the second largest national park in Pakistan after Hingol National Park.

The fauna comprises Indian leopards, striped hyenas, Indian wolves, ratels, urials, chinkara gazelles and rare Sind wild goats.

Blackbuck antelopes are kept in enclosures for a reintroduction project at Kirthar National Park. Most large predators have been killed with the last leopard shot in 1977.

The park is accessible by four wheel drive vehicles while two rest houses belonging to the Sindh Wildlife Department are available for tourist accommodation.